Reporter pathway analysis from transcriptome data: Metabolite-centric versus Reaction-centric approach

Reporter pathway analysis from transcriptome data: Metabolite-centric versus Reaction-centric approach

A systems-based investigation of the effect of perturbations on metabolic machinery is crucial to elucidate the mechanism behind perturbations. One way to investigate the perturbation-induced changes within the cell metabolism is to focus on pathway-level effects. In this study, three different perturbation types (genetic, environmental and disease-based) are analyzed to compute a list of repor...

From Process-Centric to Data Centric Replication

Analysis of Data-Centric Workfows

Workflows centered around data have become pervasive in a wide variety of applications, including health-care management, ecommerce, business processes, scientific workflows, and e-government. Such workflows are often very complex and involve numerous interacting actors. They are prone to costly bugs, whence the need for static analysis in order to verify critical properties. Analysis tools are...

An ERP-centric Master Data Management Approach

Both, ERP and MDM target integration: ERP follows a business process centric approach and integrates master data along value chains into one ERP system. MDM follows a broader approach and targets providing an enterprise-wide single version of the truth of selected master data objects and distribution of them to the different target IT systems. ERP and MDM include overlapping master data managem...

Cloud Resource Orchestration: A Data-Centric Approach

Cloud computing provides users near instant access to seemingly unlimited resources, and provides service providers the opportunity to deploy complex information technology infrastructure, as a service, to their customers. Providers bene t from economies of scale and multiplexing gains a orded by sharing of resources through virtualization of the underlying physical infrastructure. However, the...